Sorafenib is a cancer treatment and is also known by its brand name, Sorafenat
It is a treatment for:
- kidney cancer that has spread
- a type of liver cancer called hepatocellular carcinoma
- some types of thyroid cancer when radioactive iodine treatment has not worked
How it works
Sorafenib is a type of biological therapy called a protein tyrosine kinase inhibitor (TKI). Tyrosine kinase is a protein which acts as a chemical messenger (an enzyme). There are a number of different tyrosine kinases that encourage cancer cells to grow.
Sorafenib blocks some of the protein kinases and is called a multi kinase inhibitor. It works in two ways. It stops signals that tell cancer cells to grow. It also stops cancer cells forming new blood vessels, which they need to grow. Treatment that stops blood vessels forming is called anti-angiogenesis treatment.
How you have it
Sorafenib is a tablet you take with a glass of water. You should take it either without food or with a meal that contains low amounts of fat. A high fat meal may make sorafenib work less well. If you have a high fat meal, take the tablets at least 1 hour before or 2 hours afterwards.
You take sorafenib twice a day.
You must take tablets according to the instructions your doctor or pharmacist gives you.
You should take the right dose, not more or less.
Never stop taking a cancer drug without talking to your specialist first.
When you have it
You usually carry on taking it for as long as it is controlling the cancer.
Tests during treatment
You have blood tests before starting treatment and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
Other medicines, foods and drink
Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.
Pregnancy and contraception
This treatment might harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment with this drug. Talk to your doctor or nurse about effective contraception before starting treatment.
Loss of fertility
We don’t know how this treatment might affect fertility. You may not be able to become pregnant or father a child after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.
Some men might be able to store sperm before starting treatment. Some women might be able to store eggs or embryos before treatment.
Don’t breastfeed during this treatment because the drug may come through in your breast milk.
Treatment for other conditions
Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.
Don’t have immunisations with live vaccines while you’re having treatment and for at least 6 months afterwards.
In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and shingles vaccine (Zostavax).
- have other vaccines, but they might not give you as much protection as usual
- have the flu vaccine
- be in contact with other people who’ve had live vaccines as injections
Avoid contact with people who’ve had live vaccines taken by mouth (oral vaccines). This includes the rotavirus vaccine given to babies. The virus is in the baby’s urine for up to 2 weeks and can make you ill. So, avoid changing their nappies for 2 weeks after their vaccination if possible. Or wear disposable gloves and wash your hands well afterwards.
You also need to avoid anyone who has had oral polio or typhoid vaccination recently.